A papule is an area of abnormal skin tissue that is less than 1 centimeter around. A papule has distinct borders, and it can appear in a variety of shapes. Papules are often called skin lesions, which are essentially changes in the color or texture of your skin.
-Papules and pustules are the result of an increase in oil and bacteria trapped inside the pore by dead skin cells. Papules occur when the clogging causes a hair follicle to become inflamed. When this happens, the body's immune system sends white blood cells to fight the infection.
I think you're talking about histones. Histones are proteins found in eukayotic cell nuclei. Histones are what DNA wrap around so it fits inside the nucleus and helps with the formation of chromosomes.