Metaphase leads to anaphase, during which each chromosome's sister chromatids separate and move to opposite poles of the cell. Enzymatic breakdown of cohesin — which linked the sister chromatids together during prophase — causes this separation to occur.
Anaphase is the answer. In metaphase the chromatids line up next to each other and the spindle attaches to the centroid. In anaphase, the chromatids are pulled apart into opposing sides of the cell by the spindle fiber
