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Active uptake (which I think you mean active transport) is important when the concentration gradient is against that of a certain substance, so it doesn't cross the membrane through diffusion or passive transport. It is sometimes necessary if a substance needs to move across a membrane but can't do so due to electrical charge or that there is a substance on the other side of the membrane preventing diffusion.
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Structure in a chromosome that holds together the two chromatids
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well we need the photo to see what animal its asking
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They act to regulate the expression of specific genes (androgen-responsive)
Explanation:
Testosterone is a reproductive hormone in male humans. Testosterone as well as its closely related hormones e.g dihydrotestosterone, all belong to a class of hormones called "Androgens".
Androgens operate by entering into a cell and binds with specific androgen-receptor proteins (AR proteins). This contact activates the AR proteins, forming an androgen-receptor complex.
This complex then translocates into the nucleus of specific cells to bind to the DNA. Once it binds, it either inhibits or promotes the expression of specific genes (androgen-responsive). Hence, AR proteins are transcription factors because they play a significant role in regulating transcription of specific genes i.e. turning 'on' or 'off' of specific genes.
This process helps to direct the development of male sexual characteristics.