In the late 1800s during the cuban rebellion against Spain 1868-1878 over 80 per cent of Cubas exports went to the US. During this time frame much investment and purchasing of land by Americans and American Companies took place. As time passed the US and Cuba further increased economic activities making them vital to each others growing economies.
Assuming you're referring to the same time period as before, compared with the rest of Europe, northern Italy had many "trading routes" that stretched far beyond the confines of the country itself.
