Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
the equator gets the most sunlight
Explanation:
thia is because of the way that the earth is tilted on its axis.
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Answer:
Hello. You did not enter the answer options, but the factor that most directly influences a measurable result in an experiment is the manipulation of the variables.
Explanation:
In an experiment, the manipulation of variables becomes highly important so that it is possible to measure, that is, evaluate the result. This is because it is the variables that express values that represent the characteristics that are being analyzed and studied within the experiment. Therefore, the manipulation between them must be done in a very rational and balanced way so as not to modify the values shown by them, changing the data and generating false or immeasurable data.
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