Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Alfred Russel Wallace, a biologist, naturalist and anthropologist who studied life in the tropics of Indonesia came up with the same idea of natural selection as Charles Darwin and prompted Darwin to publish his Origin of Specie sooner rather than later. He also studied the geographic distribution of species and as as well he was a social activist who criticized capitalism and warned of damage to the environment from man's economic activities.
<span>The heart contains four chambers: upper left atria, upper right atria, lower left ventricle and the lower right ventricle. Oftentimes, the right atria and right ventricle are together referred to as the "right heart" and the left atria and left ventricle are referred to as the "left heart", however there are still four separate chambers.</span>
Answer:
In the leaves, small pores allow water to escape as a vapor. Of all the water absorbed by plants, less than 5% remains in the plant for growth.
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