Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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Even though they may be teratogenic, opioids were prescribed to percent of pregnant women on medicaid.
Opioids are a group of chemicals that are naturally occurring in the opium poppy plant. They act on the brain to create a range of effects, including the numbing of pain with many of these drugs.
Opioids can be either legal street drugs like heroin or prescription prescriptions that are frequently referred to as painkillers.
Opioids, often known as narcotics, are different from over-the-counter pain relievers like aspirin and Tylenol despite the fact that they also reduce pain.
opiods research has been and continues to be essential in addressing a variety of current global aims and issues, including maintaining food, water, and energy security for a healthy population on a planet that is habitable.
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Weathering and soil formation.
Answer:
Can someone pls answer my questions plssss?
Explanation:
<span>The exfoliative toxin is responsible for a skin disease called staphylococcal scalded skin syndrome. This exotoxin, exfoliatin is produced by Staphylococcus aureus and it induces the formation of fluid-filled blisters with easily ruptured, thin walls, usually in infants. Exfoliatin has the protease activity which causes peeling of the skin by destroying adhesion between keratinocytes (skin cells).</span>