Answer:
Benjamin Franklin
Explanation:
Benjamin Franklin was one of the founding fathers of America and he is well known for his many inventions as well. All the mentioned inventions were invented by him along with his contribution towards development of U.S Postal system.
The answer to your question is A carpel
Enzymes can be denatured unfolded by heat or chemicals.
<h3>What are enzymes?</h3>
Enzymes are proteins that are found in living organisms which are able to increase the rate of chemical reaction and remains unchanged at the end of the reaction.
The factors that can denature enzymes include heat and chemicals. This is because:
- Higher temperatures disrupt the shape of the active site, which will reduce its activity, or prevent it from working. When the enzyme loses its shape, it is said to have been denatured.
- These environmental factors can alter the pH level of the enzyme.
Therefore, for an enzyme to perform its functions, the external factors that affects it's activities must be normal and favorable.
Learn more about enzymes here:
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Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
When energy passes from one trophic level to the next, I would guess that the two factors which decrease the total amount of energy from being passed up are:
1. An organism does not assimilate all the energy of food consumed. Within a consumer, digestion and assimilation of energy is not 100% efficient: some of the energy is lost.
2. A large proportion of energy assimilated by a producer and consumer is lost through respiration, i.e., day-to-day maintenance of metabolic processes.
