<h2>CRISPR/Cas9</h2>
Explanation:
CRISPR can be used to reintroduce dystrophin back into the KO mouse
- CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats and is used to for gene editing
- CRISPR/Cas-mediated genome editing has been shown to permanently correct DMD mutations and restore dystrophin function in mouse models
- Germline editing by injecting zygotes with CRISPR/Cas9 editing component was first done in mdx mice by correcting the mutated exon 23
- Postnatal editing of mdx mice was then achieved using recombinant adeno-associated virus to deliver CRISPR/Cas9 genome editing components and correct the dystrophin gene by skipping or deleting the mutated exon 23 in vivo
- Germline and postnatal CRISPR/Cas9 editing approaches both successfully restored dystrophin function in the mice and same technique can be used for KO mouse model
Answer:
MHCI
Explanation:
Major histocompatibility complex I (MHCI) is present on the nucleated cells of the body. Endogenous pathway represents the pathway of MHC class I molecules.
MHCI display peptide fragment of proteins to the cytotoxic T cells with the help of CD8 ( Cluster of differentiation). CD8 binds with the MHCI and expressed on the surface of cytotoxic T cells.
Thus, the correct answer is option (D).
A biologist .....they study living things only.
Answer:
gdk
and got tooka killed Explanation:
