Which of the following results would provide support for the thrifty genotype hypothesis?A. alleles involved in the development
of diabetes show signatures of positive selection in the pastB. mice with diabetes reproduce less under conditions of persistent food stressC. genome sequencing of 60,000 year old human fossils reveals that alleles linked with diabetes were at lower D. frequency in the pastE. all of the aboveF. none of the above
We have investigated the evidence for positive selection in samples of African, European, and East Asian ancestry at 65 loci associated with susceptibility to type 2 diabetes (T2D) previously identified through genome-wide association studies. Selection early in human evolutionary history is predicted to lead to ancestral risk alleles shared between populations, whereas late selection would result in population-specific signals at derived risk alleles. By using a wide variety of tests based on the site frequency spectrum, haplotype structure, and population differentiation, we found no global signal of enrichment for positive selection when we considered all T2D risk loci collectively. However, in a locus-by-locus analysis, we found nominal evidence for positive selection at 14 of the loci. Selection favored the protective and risk alleles in similar proportions, rather than the risk alleles specifically as predicted by the thrifty gene hypothesis, and may not be related to influence on diabetes. Overall, we conclude that past positive selection has not been a powerful influence driving the prevalence of T2D risk alleles.
These are the possible genotypes RR, Rr, Rr, rr
First 3 carries dominant gene for tongue rolling, so they can do it,
while the 4th genotype rr is homologous for recessive, and he/she can't
perform tongue rolling.
"Apical Meristem Tissue" is the part of the plant among the following choices given in the question where the activity in the plant stem could have caused this. The correct option among all the options that are given in the question is the first option or option "A". I hope that the answer has come to your help.
