Question

An oligomeric enzyme transitions from a T to R state as substrate binds, producing positive cooperativity. If a heterotropic allosteric activator binds the enzyme, the Hill coefficient will______________.
A. DecreaseB. IncreaseC. Remain unchanged

Answer 1

Answer:

Increase

Explanation:

Oligomeric enzyme have more than one polypeptide chain and the enzyme show positive cooperativity. It means that binding of the ligand to the enzyme will help other ligands to bind to the enzyme. Hill cofficient is used to measure the determining the degree of cooperativity of the binding between enzyme and substrate or ligand. As in this case, allosteric enzyme show positive cooperativity, its Hill cofficient will increase