Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Based on the information we have, we can confirm that when Simon is looking for the bottle containing pleural fluid, he should gravitate towards the bottle with a clear or slightly yellow liquid.
<h3>Why should he choose this bottle?</h3>
Simon is looking for pleural fluid. This means that he is looking to find a bottle with a sample of the fluid used by the lungs to allow breathing to take place. This liquid is described as a clear or slightly yellow-colored liquid.
Therefore, we can confirm that when Simon is looking for the bottle containing pleural fluid, he should choose the bottle with a clear or slightly yellow liquid.
To learn more about the lungs visit:
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Answer:
Benign is a non- cancerous growth on the body. a malignant tumor is a cancerous tumor.
The nurse will make these supplies available to the client:
- Oxygen
- Suction machine
- Prescribed diazepam
- Padding for the side rails
Seizures come in a variety of forms. The majority of seizures are short-lived.
The following are general actions to take to assist someone having any kind of seizure:
As soon as the seizure stops and the person regains consciousness, stay by their side. When it's over, assist the person in finding a secure seat. Tell them what happened in simple words once they are awake and speaking.
Soothe the person and maintain composure.
Verify if the wearer is sporting a medical ID bracelet or any other type of emergency identification.
Keep everyone calm, including yourself.
To make sure the person gets home securely, offer to call a taxi or a friend.
Learn more about Seizure First Aid here:
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