The statement above is TRUE.
Depressants has many negative effects, these include depression, chronic fatigue, breathing difficulties, sleep problems, etc.
Long time use of depressants can affect the immune system, weakening it considerably and making the body susceptible to many diseases including cancer.
aeorbic respiration occurs in the mitochondria
A DNA mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people. Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes. DNA mutations can affect an offspring can result in abnormal protein products. Mutations can also introduce new alleles into a population of organisms and increase the population's genetic variation.