Well for the very last sentence it would be if any of the organs shut down it could seriously hurt someone or possibly even kill them if their brain,heart or some other important organ shuts down it could kill them.
There are other minor organs where if it shuts down it wouldn't really hurt the person too much. Sorry I couldn't help you with the other ones though.
D.)The enzyme changes shape and no longer fits the substrate.
High temp causes enzymes to speed up the reaction but too much heat and the enzyme might denature, losing its shape.
Answer:
ingestion, digestion, absorption, elimination
Explanation: