The answer is Troposphere.
The circle part about the circulatory sysytem
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Cloud Formation can cause cloud droplets which then affect regional climate. In creating the droplets that form clouds and lead to precipitation
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While both will equate changes in a genetic chain, deletion would have more severe consequences. A substitution mutation usually only causes minor disorders and diseases, like sickle cell anemia. Whereas deletion causes much more serious diseases, like cystic fibrosis, and turner syndrome which is where a female is born with only one X chromosome.
