I would say internationally i kind of dont get the question that is bieng asked
Answer:
The lure of profit pushed explorers to seek new trade routes to the Spice Islands and eliminate Muslim middlemen. ... Trade for luxuries such as spices and silk inspired European explorers to seek new routes to Asia
Explanation:
Hope it helps!!! :D
Smallpox was had the most dramatic effect on Native Americans. It was quite sad, actually. They were given blankets and clothes that were already infected with smallpox.