Organic molecules can range in size from simple molecules to complex structures containing thousands of atoms! Although carbon is present in all organic compounds, other elements such as hydrogen , oxygen , nitrogen , sulfur and phosphorus are also common in these molecules.
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- Methylation of histone tails in chromatin can promote condensation of the chromatin.
- DNA is not transcribed when chromatin is packaged tightly in a condensed form.
- Acetylation of histone tails is a reversible process.
- Some forms of chromatin modification can be passed on to future generations of cells.
- Acetylation of histone tails in chromatin allows access to DNA for transcription.
Histone modifications are post-translational modifications of histone protein that can affect gene expression by altering chromatin structure or recruiting histone modifiers.The most common modifications are methylation, phosphorylation, acetylation and ubiquitylation. All of them affect the binding affinity between histones and DNA and thus loosening (gene activation) or tightening (gene repression) the condensed DNA.
Histone methylation is a transfer of methyl group by histone methyltransferases to lysine or arginine amino acid of protein. Effect of methylation depends on the type of protein that is modified. Demethylation is the reverse process.
Histone acetylation is the process of adding of an acetyl group(by histone acetyltransferases) to histone proteins and it can also activate or inhibit the gene expression. Deacetilation is reverse process.
This figure illustrates 3 hypotheses of how a cancer stem cell may arise: (1) A stem cell undergoes a mutation, (2) A progenitor cell undergoes two or more mutations, or (3) A fully differentiated cell undergoes several mutations that drive it back to a stem-like state.
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