The substrate and the active site both need to fit together perfectly in order for the enzyme to work properly. If their shape is changed, typically through heat or a change in pH, the enzyme will not work.
Pikachurin, also known as AGRINL and EGF-like, fibronectin type-III and laminin G-like domain-containing protein, is a protein that in humans is encoded by the EGFLAM gene
(C) it's genes and it's environment.
