Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:( answer for number one) an essential nutrient for the production of amino acids, proteins, nucleic acids. ( number 2 ) for the growth, maintenance, and repair of all tissues and cells, and for the production of the genetic building blocks, DNA and RNA
Answer: i cinque isomeri possibili per l'esano sono n-esano, 2-metil pentano, 3-metil pentano, 2, 3-dimetilbutano e 2, 2-dimetilbutano. - 2-metil pentano è anche chiamato isoesano. - 2, 2-dimetil butano chiamato anche Neoesano.
Explanation:
i believe the answer is Abrasion and Impact. Hope this helps :-)
