Question

Most water-soluble hormones exert their effects through the second messenger cyclic AMP (cAMP). This activity will test your understanding of the events that occur during cAMP signaling. Drag the events of cAMP signaling in the correct sequence from left to right.

Answer 1

Answer:

cAMP dependent pathway is important for processing of life.

Explanation:

cAMP pathway is also called as adenynyl cyclase pathway.

This mechanism requires different steps like-

1. G protein coupled receptor is a integral protein that is activated by different external stimuli which binds with the specific ligand.
2. Extracellular ligand causes activation of GPCR which in turn is responsible for conformational change  in the receptor and allows it to bind with the intracellular heterotrimeric G protein complex.
3. The Gα  stimulate G protein complex to exchange GDP for GTP and then the complex is released.
4. Activated Gα binds with adenylate cyclase and catalyzes ATP to form cyclic AMP.
5. Activation of cAMP leads to the activation of nucleotide gated ion channel, and PKa(Protein kinase A) which is also called as cAMP dependent enzyme.
6. Once, PKA is activated,it causes phospholylation of other proteins like AMPA receptor,transcription factors which regulate gene expression, and convert glycogen into glucose.