<span>The colonists at Jamestown, the second English colony in what would later become the United States, faced a slew of fatal problems. A prolonged drought that made growing food crops and finding fresh water difficult led to starvation and the drinking of contaminated water, which, along with the swampy area’s plentiful mosquitoes, contributed to the spread of deadly diseases. The settlers also faced conflict with the indigenous people, poor leadership in their own community, the extreme heat and cold of Virginia’s climate, and the fact that they were, overall, woefully unprepared to survive in such harsh conditions.</span>
<span>C. She faced down a mob of angry citizens and helped save Justinian's empire</span>
A because Manichaeism is a syncretic and dualistic religious philosophy
D - Failures.
The only attempted british colony in North America before 1600 was Roanoke, Virginia, which was a total failure. England claimed several areas, including Newfoundland, but made no sustainable attempts to colonize them before 1600.