George Mason did not want the Constitution and did not want to sign it. He did not want the federal government to have a large amount of power, as this gave the government a lot power to put on citizens, like the British did to the colonists. George Mason wanted a strong central government, like the Articles of Confederation, which gives very little power to the government, and makes it so they can not regulate trade or even effectively make people obey to certain laws.
The correct answer is that the Native Americans were dying off in large numbers because of the diseases that were in the places they were working in. Hope this helps.