In spherocytosis, there is a defect in the membrane proteins of the red blood cells, specifically ankyrin and spectrin. These membrane proteins contribute to the biconcave shape of red blood cells therefore the loss of these proteins will lead the red blood cells to lose its biconcave shape--leading to abnormally shaped red blood cells (spheres) hence the name. This can lead to premature destruction of red blood cells and jaundice due to hyperbilirubinemia. Spherocytes do not hold oxygen and carbon dioxide well as spherocytes have a decreased surface area.
Natural selection is the process by which individuals with characteristics that are advantageous for reproduction in a specific environment leave more offspring in the next generation, thereby increasing the proportion of their genes in the population gene pool over time. Natural selection is the principal mechanism of evolutionary change, and is the most important idea in all biology. Natural selection, the unifying concept of life, was first proposed by Charles Darwin, and represents his single greatest contribution to science.
Natural selection occurs in any reproducing population faced with a changing or variable environment. The environment includes not only physical factors such as climate or terrain, but also living factors such as predators, prey, and other members of a population.
Mechanism of Natural Selection
The mechanism of natural selection depends on several phenomena:
• Heredity: Offspring inherit their traits from their parents, in the form of genes.
• Heritable individual variation: Members of a population have slight differences among them, whether in height, eyesight acuity, beak shape, rate of egg production, or other traits that may affect survival and reproduction. If a trait has a genetic basis, it can be passed on to offspring.
• Overproduction of offspring: In any given generation, populations tend to create more progeny than can survive to reproductive age.
• Competition for resources: Because of excess population, individuals must compete for food, nesting sites, mates, or other resources that affect their ability to successfully reproduce.
Given all these factors, natural selection unavoidably occurs. Those members of a population that reproduce the most will, by definition, leave more offspring for the next generation. These offspring inherit their parents' traits, and are therefore also likely to succeed in competition for resources (assuming the environment continues to pose the same challenges as those faced by parents). Over several generations, the proportion of offspring in a population that are descended from the successful ancestor

Uloborid spider eggs and spiderlings. In any given generation, populations tend to create more offspring than can survive to reproductive age.
increases, and traits that made the ancestor successful therefore also increase in frequency. Natural selection leads to adaptation, in which an organism's traits conform to the environment's conditions for existence.
<span>Fundamentally, the cell would cease to function and possibly die. Proteins are used for cellular repairing and chemical processes. Ribosomes are one of the most important organelles in the cell, mostly part of the rough endoplasmic reticulum. It manufactures enzymes such as proteins which will be utilized by many organelles in the cell. Microtubules are one, responsible for the framework and acts as a skeleton of the cell –cytoskeleton needs proteins, also cytoplasm and other organelles of the cell. For a prokaryote or a eukaryote cell to survive, they need protein.<span>
</span></span>
