Acetyl CoA is a feed forward activator of the enzyme <u> pyruvate carboxylase</u> ensuring sufficient oxaloacetate for the citric acid cycle to continue.
<h3>Why does acetyl-CoA stimulate pyruvate carboxylase?</h3>
Acetyl-CoA selectively activates pyruvate carboxylase. When acetyl-CoA concentrations are high, organisms use pyruvate carboxylase to divert pyruvate from the TCA cycle because acetyl-CoA is a crucial metabolite in the TCA cycle that generates a lot of energy. The production of more oxaloacetate is triggered by an excess of mitochondrial acetyl-CoA.
Acetyl coenzyme A, often known as acetyl-CoA, is a crucial component in metabolism and is involved in numerous metabolic processes. Its major job is to transport the acetyl group's carbon atoms to the Krebs cycle, where they can be oxidized to produce energy. When there is an abundance of acetyl CoA available, the mitochondrial enzyme pyruvate carboxylase (PC) catalyzes the conversion of pyruvate to oxaloacetate.
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