N-acetylglucosamine phosphotransferase is a golgi-localized enzyme that catalyzes the first step in the synthesis of the mannose 6-phosphate recognition marker on lysosomal acid hydrolases.
<em><u>The loss of function of this enzyme results in impaired lysosomal targeting of the acid hydrolases and decreased lysosomal degradatio</u></em>n.
Mannose 6-phosphate receptor sorts lysosomal hydrolases in trans Golgi Network; the first step is the recognition of lysosomal hydrolyses in the Golgi apparatus by N-acetylglucosamine phosphotransferase.
The enzyme has both the catalytic sites which binds both high mannose N-linked oligosaccharides and UDP-GlcNAc, and recognition site that binds to a signal patch present only on the surface of lysosomal hydrolases.
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The study of the lives of early human communities through the examination of their physical remains. Objects made by humans that are unearthed by archaeologists. ... The study of the earth, especially it's rock forms.
