Answer:
- In terrestrial environments: increasing CO2 levels cause an increased photosynthetic rate
- In aquatic environments: increasing CO2 levels cause an increase in water acidity
- In both terrestrial and aquatic environments: increasing CO2 levels lead to an overall increase in the average temperature (global warming)
Explanation:
In terrestrial ecosystems, rising carbon dioxide (CO2) levels increase the rate of photosynthesis (since CO2 is one of the reactants in photosynthesis), thereby also increasing plant growth. Moreover, in aquatic ecosystems, rising CO2 concentrations increase the levels of this gas dissolved on the surface of the oceans. This increases the acidity of the oceans, thereby modifying habitats and food web structures. The increasing acidity of the oceans also reduces the amounts of carbonate, which difficult for aquatic species (e.g., corals) to form their shells/skeletons. Finally, CO2 is a greenhouse gas that contributes to the increase in the average temperature by absorbing solar radiation that would otherwise have been reflected by the Earth's surface, and this increase in the temperature negatively affects life in both terrestrial and aquatic environments.
False, Xylem transports water.
Answer:
C. NAD⁺
Step-by-step explanation:
NADH is oxidized to NAD⁺ in Complex I of the Electron Transport Chain.
NADH ⟶ NAD⁺ + H⁺ + 2e⁻
The electrons continue through the Electron Transport Chain, and the NAD⁺ is used in three places during the Krebs Cycle.
(a) Isocitrate to oxalosuccinate
Isocitrate + NAD⁺ ⟶ oxalosuccinate + NADH + H⁺
(b) α-Ketoglutarate to succinyl-CoA
α-ketoglutarate + NAD+ + CoA → succinyl CoA + CO₂ + NADH
(c) Malate to oxaloacetate
Malate + NAD⁺ ⟶ oxaloacetate + NADH + H⁺
The NADH produced by these three reactions can then be used by Complex I in the Electron Transport Chain.
<span> c)atp has three phosphate groups, while adp has two phosphate groups. </span>
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
