natural selection, bc it is the process whereby organisms better adapted to their environment tend to survive and produce more offspring
<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Microorganisms can be divided into two groups:
1. Archea
• Archea are prokaryotic unicellular organisms without cell nucleus or other membrane bound-organelles.
• Their membrane is built from ether lipids, which differs them from bacteria’s cell membrane.
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2. Bacteria
• Bacteria are also unicellular prokaryotic organisms.
• Bacterial cell membranes are made from phosphoglycerides with ester bonds. Bacterial genome is in a form of circular chromosome.
• They reproduce by binary fission or by budding.
Besides, prokaryotes (Archea and Bacteria) a large number of eukaryotes are also microorganisms. Unicellular eukaryotes contain organelles such as the cell nucleus, the Golgi apparatus and mitochondria. Usually, they reproduce asexually by mitosis. An example of eukaryotic microorganism is Protist.
On a giant pasteboard with pictures, and explanation on what each type of engineer.
natural selection is an species wich are adapted to their environment
