Question

anide 5) amytal Match each compound with the complex it inhibits. 1) rotenone A) complex IV 2) CO B) complex III 3) antimycin C) complex I 4) cyanide 5) amytal 1:B; 2:C; 3:A; 4:A; 5:C 1:B; 2:A; 3:C; 4:C; 5:B 1:C; 2:B; 3:A; 4:A; 5:C 1:C; 2:A; 3:B; 4:A; 5:C

Answer 1

Answer:

1:C; 2:A; 3:B; 4:A; 5:C  is the right answer.

Explanation:

1) rotenone ------------------C) complex I

2) CO -------------------------A) complex IV

3) antimycin -----------------B) complex III

4) cyanide ------------------A) complex IV  

5) amytal ---------------------C) complex I

Answer 2

Answer:

1:C; 2:A; 3:B; 4:A; 5:C

Explanation:

1. Rotenone inhibits NADH dehydrogenase (also known as Complex I) by blocking transfer of electrons from iron sulfur centers to CoQ.

2. Carbon Monoxide inhibits cytochrome c oxidase (also known as Complex IV) of the electron transport chain. It competes with oxygen for its binding site.

3. Antimycin inhibits cychrome c reductase (also known as Complex III) by binding to its Qi site and blocking the oxidation of ubiquinone.

4. Cyanide  like carbon monoxide, it competitively inhibits cytochrome c oxidase (also known as Complex IV) by competing with oxygen for the binding.

5. Amytal inhibits NADH dehydrogenase (also known as Complex I) by binding to the ubiquinone side of  NADH.