The answer is "D"
The body's first line of defense is also known as Innate immunity and incudes mucous membranes. Both the intact skin and mucous membranes of the body offer a high degree of protection against pathogens.
A good example is the mucous membrane of the respiratory tract. It is lined up with cilia and covered with mucus. The coordinated beating of the cilia drives the mucus up to the nose and mouth where the trapped bacteria can be expelled.
(Lymph nodes and white blood cells belong to the second line of defense, not the first)
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
Duplication is a type of mutation that involves the production of one or more copies of a gene or region of a chromosome. Gene and chromosome duplications occur in all organisms, though they are especially prominent among plants. Gene duplication is an important mechanism by which evolution occurs.
Adhesion is defined as a component of water , an attraction that occurs between two different substances like water and the cell walls of plant cells.
For instance:
A tree requires to be able to transport water from the roots to the leaves atop the tree over a long distance. The Water molecules will stick to the xylem in the method called as adhesion.
<span> </span>
The sole reason why red blood cells are unable to replace damaged proteins is that red blood cells lack DNA and cell organelles such as nucleus, ribosomes and mitochondria which are crucial for protein synthesis, assembly and repair. In other words they lack both the information and the machinery for making or repair of proteins.
Due to lack of DNA and cell organelles, red blood cells cannot be able satisfy the central dogma which summarizes synthesis of proteins as DNA → RNA → proteins.
DNA has the genetic information on how proteins should be made, RNA is responsible for transferring the information from DNA in the cell nucleus to the ribosomes in the cytoplasm, then translating or decoding this information, which results in the making of protein.
