The first major difference between prokaryote and eukaryote gene expression is the location. Due to lack of compartments (nucleus) prokaryotic gene expression (both transcription and translation) occurs within the cytoplasm (genetic material is located within the cytoplasm). So, transcription and translation in prokaryote occurs simultaneously. Gene expression in eukaryote occurs in both the nucleus (transcription) and cytoplasm (translation).
The steps of regulation of gene expression are also dissimilar, in prokaryotic cell, transcription is mostly the main point of regulation (eukaryote have transcription, post-transcription, translation, and post-translation regulation together with epigenetic regulation).
Loss of Rb, an important part of the G1-S transition checkpoint, can result in uncontrolled cell cycle progression and cancer. All of the following would mimic loss of Rb except constitutively active Ras GTPase activating protein. Correct answer: letter E.
Constitutively active Ras GTPase activating protein would not mimic loss of Rb, because it would not directly result in uncontrolled cell cycle progression.
<h3>What is Retinoblastoma (RB)?</h3>
Rb is an important tumor suppressor protein that works to inhibit cell cycle progression by preventing the activation of E2F transcription factors. Constitutively active Ras GTPase activating protein would not directly interfere with the Rb-E2F pathway, which is necessary for uncontrolled cell cycle progression and cancer.
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So that the cell itself can maintain homeostasis and balance out its necessities
