Question

Cell cycle checkpoints are an important feature of a dividing cell to reduce errors that can occur in various stages of the cell cycle. Loss of Rb, an important part of the G1-S transition checkpoint, can result in uncontrolled cell cycle progression and cancer. All of the following would mimic loss of Rb except:
Constitutively active G1-CDK Constitutively active ERK Constitutively active E2F Constitutively active Myc Constitutively active Ras GTPase activating protein

Answer 1

Loss of Rb, an important part of the G1-S transition checkpoint, can result in uncontrolled cell cycle progression and cancer. All of the following would mimic loss of Rb except constitutively active Ras GTPase activating protein. Correct answer: letter E.

Constitutively active Ras GTPase activating protein would not mimic loss of Rb, because it would not directly result in uncontrolled cell cycle progression.

What is Retinoblastoma (RB)?

Rb is an important tumor suppressor protein that works to inhibit cell cycle progression by preventing the activation of E2F transcription factors. Constitutively active Ras GTPase activating protein would not directly interfere with the Rb-E2F pathway, which is necessary for uncontrolled cell cycle progression and cancer.

Learn more about the cell cycle:

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