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Dafna11 [192]
3 years ago
12

Can anyone help me with my science?

Biology
1 answer:
scoray [572]3 years ago
8 0
Your answer would be Latent heat of fusion. Hope this helps!
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Based on the definitions of pharmacophore and privileged structure, outline essential structural features a 1,4-dihyrdopyridine
stiv31 [10]

Answer:

Explanation:

Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.

Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.

1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.

1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.

A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,

antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .

Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.

2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.

6 0
3 years ago
Choose the true statement(s) concerning the eukaryotic glycocalyx
Illusion [34]

Explanation:

eukaryotic glycocalyx is present in prokaryotic cells, eukaryotic cells can also have glycocalyces especially single celled eukaryotic organisms.

8 0
3 years ago
Do you think that fungal cells have turgor pressure? Design an experiment to test your hypothesis.
valentinak56 [21]
Yes because they still need water to function. Fungal cells are interesting in that they have a cell wall like plant cells, but that cell wall ismade up of chitin.<span>They are also heterotrophic, normally feeding on dead organic material. Hope it helps. </span>
3 0
3 years ago
Which is the primary consumer in this food chain? rabbit grass snake hawk
Arturiano [62]
Rabbit. It's the only herbivore in this chain.
6 0
3 years ago
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T or F... The Earth's climate changed naturally BEFORE humans existed. * <br> True<br> False
DENIUS [597]

Answer:

Explanation:

true

6 0
3 years ago
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