<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
That statement is true!!!
I guess because of concentration.....it stops !
Answer:
The correct option will be Option B (study only physical aspect of primates).
Explanation:
- The significant components of that same endangered as well as surviving primates are analyzed by a primatologist. Also, the primates come to terms with either the molecular and physiological elements.
- A primer broader knows a great deal about everything from the bones of the primates. We also integrated depth of understanding of both biologizes including primate behavior.
The other choices don't apply to the specified scenario. So option B will be the perfect option for b.
Answer:
Pwave
Explanation:
The P wave can move through solid rocks and fluids, like water or the liquid layers of the earth. So yes, P waves is the right answer. I hope I help.
