1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
shusha [124]
3 years ago
15

In sickle-cell disease, as a result of a single amino acid change, the hemoglobin tetramers associate with each other and assemb

le into large fibers. Based on this information alone, we can conclude that sickle-cell hemoglobin exhibits ________.
Biology
1 answer:
Phoenix [80]3 years ago
7 0

Answer:

One of the common genetic disorders is sickle cell anemia, in which 2 recessive alleles must meet to allow for destruction and alteration in the morphology of red blood cells. This usually leads to loss of proper binding of oxygen to hemoglobin and curved, sickle-shaped erythrocytes. The mutation causing this disease occurs in the 6th codon of the HBB gene encoding the hemoglobin subunit β (β-globin), a protein, serving as an integral part of the adult hemoglobin A (HbA), which is a heterotetramer of 2 α chains and 2 β chains that is responsible for binding to the oxygen in the blood. This mutation changes a charged glutamic acid to a hydrophobic valine residue and disrupts the tertiary structure and stability of the hemoglobin molecule. Since in the field of protein intrinsic disorder, charged and polar residues are typically considered as disorder promoting, in opposite to the order-promoting non-polar hydrophobic residues, in this study we attempted to answer a question if intrinsic disorder might have a role in the pathogenesis of sickle cell anemia. To this end, several disorder predictors were utilized to evaluate the presence of intrinsically disordered regions in all subunits of human hemoglobin: α, β, δ, ε, ζ, γ1, and γ2. Then, structural analysis was completed by using the SWISS-MODEL Repository to visualize the outputs of the disorder predictors. Finally, Uniprot STRING and D2P2 were used to determine biochemical interactome and protein partners for each hemoglobin subunit along with analyzing their posttranslational modifications. All these properties were used to determine any differences between the 6 different types of subunits of hemoglobin and to correlate the mutation leading to sickle cell anemia with intrinsic disorder propensity.

Explanation:

You might be interested in
What are bacteria that can produce their own food without using the sun's energy called?
BaLLatris [955]
That would be Chemoautotrophic
3 0
1 year ago
What happens when the cycling of matter in ecosystems is disrupted
V125BC [204]

Answer:

When cycling of matter in the ecosystems is disrupted, the whole ecosystem will be adversely affected. Matter includes living organisms such as plants, animals and microorganisms while non living things such water, air and nutrients etc. If plants are removed from the ecosystem system, then the whole ecosystem is destroyed because plants are the producer which make food for herbivores. These herbivores are eaten by carnivores and so on.

5 0
3 years ago
Human height is variable with a wide range of phenotypes because it is affected by the
cupoosta [38]

Answer:

polygenic trait

Explanation:

polygenic trait

5 0
3 years ago
Which phase of the moon follows the first quarter moon?
kow [346]
This next phase is a Waxing Gibbous. Hope this helps!
3 0
3 years ago
What part of the cell is the most important to the function of the organism
OverLord2011 [107]

Answer:

mitochondria because it provides the cell with energy

4 0
3 years ago
Other questions:
  • Which kind of organism is an autotroph? consumer producer decomposer herbivore
    10·2 answers
  • Which was not produced by volcanic outgassing?
    12·2 answers
  • In a high-pressure system,a<br> A:rises and cools.<br> B:sinks and warms.
    14·1 answer
  • What is a body cavity called?
    10·1 answer
  • What energy do mountainous region would be likely a source?
    14·1 answer
  • Local authorities need to be on the lookout to stop hazardous waste _____ who get around laws using tactics such as bribes, fals
    10·1 answer
  • The term alternative energy best discibes?
    15·1 answer
  • May you please answer part a and b.
    10·2 answers
  • Shows its specific trait when both parents pass the gene to the offspring *
    9·1 answer
  • Which two organisms most likely have a recent common ancestor? Explain.
    5·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!