When working on improvement, you should balance your confidence in succeeding against the possible repercussions of a test that does not result in improvement. Depending on your level of belief and the risks involved, you should scale back your initial PDSA cycle.
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What is PDSA cycle?</h3>
- PDCA, also known as the Deming circle/cycle/wheel, the Shewhart cycle, the control circle/cycle, or plan-do-study-act, is an iterative design and management technique used in business for the control and continuous improvement of processes and products (PDSA).
- The PDCA cycle can also be expressed as OPDCA, where the extra "O" stands for observation or, in some versions, "Observe the current condition." This emphasis on observation and current condition is in line with the literature on lean manufacturing and the Toyota Production System. The PDCA cycle can be traced back to S with Ishikawa's modifications. Tokyo Institute of Technology's Mizuno in 1959.
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A role of nitric oxide (NO) in the increased sensitivity of the aging kidney to injury has been established.
<h3>What is drug toxicity ?</h3>
Drug toxicity is characterised as a wide range of negative effects brought on by the use of drugs at therapeutic or non-therapeutic dosages.
- The rate of cellular apoptosis in the kidney increases with age, resulting in fewer functional nephrons and a decrease in GFR and creatinine clearance ratio. This decrease in renal functional reserve makes the kidney more vulnerable to AKI.
- The mechanisms-based (on-target) toxicity, immunological hypersensitivity, off-target toxicity, and bioactivation/covalent modification are a few of the causes of drug toxicity that can be grouped in different ways.
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