Question

The drug cytochalasin B blocks the function of actin. Which of the following aspects of the cell cycle would be most disrupted by cytochalasin B?
A) spindle formation
B) spindle attachment to kinetochores
C) DNA synthesis
D) cell elongation during anaphase
E) cleavage furrow formation and cytokinesis

Answer 1

The correct answer is: E) cleavage furrow formation and cytokinesis

Cytochalasin B (cytos-cell and chalasis-relaxation) is a molecule which inhibit network formation by actin filaments by blocking monomer addition. As a result, itshortens actin filaments. This molecule is involved in cytoplasmic division where it blocks the formation of contractile microfilaments. One of the microfilament’s function includes cytokinesis and formation of cleavage furrow so these functions are affected by cytochalasin B.