In a prominent model of self-administration developed by George Koob, rats are allowed to self-administer cocaine for either 1 hour each day (short access) or 6 hours each day (long access).
B and C for sure but A could sometimes be considered
Answer:
increase in the number of neurons in the hippocampus
Explanation:
Studies shows that loss of number neurons in the hippocampus contribute to the pathophysiology of depression. Therefore, studies have been carried out to determine the effect of antidepressants on hippocampal neurons. Studies shows that antidepressants increase cell proliferation and also increase hippocampal neuron number i.e increased in the number of neurons in the hippocampus, by the process called neurogenesis.
Therefore, since Selective Serotonin Reuptake Inhibitors (SSRIs) is an antidepressant, when administered to rats it is most likely to find an increase in the number of neurons in the hippocampus when analyzing the brain tissues.
