Alexander the Great is important because by the age of thirty he had created one of the largest empires in ancient history. He was the ancient ruler of Macedonia, what is now north eastern Greece and as ruler he conquered most of the civilized world, from Greece to Egypt, Persia and India. He is known as one of the greatest commanders of all time and was undefeated in battle.
The effects of the Black Death were many and varied. Trade suffered for a time, and wars were temporarily abandoned. Many labourers died, which devastated families through lost means of survival and caused personal suffering; landowners who used labourers as tenant farmers were also affected.
The Mandate of Heaven concept helped individuals or groups of people gain power in a civilization. An individual would claim that they had received a Mandate of Heaven which granted them divine recognition to rule. By claiming their authority came from the gods, the people would accept them as their leader.
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I would say that they were nurses for injured men.