Answer:
The correct answer is option A. "The contents of blood come into closer contact with tissues in a closed system than an open system".
Explanation:
In a closed circulatory system, the blood has an specific path, circulating from arteries to veins and to smaller blood vessels throughout the body. This is in contrast with open circulatory systems at which the blood is not contained in arteries or veins but it suffuses the body. A closed circulatory system have many advantages over open circulatory system, however in a closed circulatory system the contents of blood are not into closer contact with tissues in than an open system. Actually, in an open circulatory system the blood is in closer contact with tissues.
The three cellular components, which takes part in the process of metabolism and are affected by the modifications in temperature are ribosomes, cell membrane, and enzymes.
All these are formed of a certain type of protein, which can become denatured when exposed to high enough heat or stop gets functioning at too low temperature. The high temperature can disrupt the non-polar hydrophobic interactions and hydrogen bonds. This takes place as heat enhances the kinetic energy and makes the molecules to throb so briskly and viciously that the bonds get disordered.