Briefly, the DNA in our cells is translated by cell machinery to make proteins. ... The DNA sequence of a gene determines the amino acid sequence of the resulting protein. Thus, any changes in DNA sequence can result in changes in protein function. This is called a mutation. Hope this helps
Point mutations are the substitution of a single nucleotide, which creates a different codon and therefore a different amino acid. the incorporation of a different amino acid in the protein can completely disrupt the normal function of proteins.