Answer:
Constitutive activation is the alteration of a protein or signaling pathway such that it is functional or engaged even in the absence of an upstream activating event. For example, RasD is constitutively active because it cannot bind GAP and therefore remains in the GTP-bound, active state even when cells are not stimulated by growth factor to activate a receptor tyrosine kinase.
Constitutively active Ras is cancer promoting because cells will proliferate in the absence of growth factors, and thus normal regulatory mechanisms for cell proliferation are bypassed.
(a) A mutation that resulted in Smad3 binding Smad4, entering the nucleus, and activating transcription independent of phosphorylation by the TGFβ receptor would render Smad3 constitutively active.
(b) A mutation that made MAPK active as a kinase and able to enter the nucleus without being phosphorylated by MEK would render MAPK constitutively active.
(c) A mutation that prevented NF-KB from binding to IK-B or that allowed NF-KB to enter the nucleus and regulate transcription even when bound to IK-B would render NF-KB constitutively active.
Objective means that they are "facts", and do not include personal thoughts and beliefs (which is subjective).
In this case, your answers are:
1) Fact:
Facts are made based on data and analysis, and are supported by details and other known "facts" or <em>truths</em>. This means that they are right in any circumstances in most cases, or at least in the given circumstance that is provided.
2) Data:
Data is used to support the fact, which is objective. Without data, the claim would be seen as a opinion, or subjective, in meaning, a "I feel that it is this way". Without data, you will not have facts.
It is not:
3) Opinion:
Opinion is the antonym of Fact, and so if Fact is a answer choice, then Opinion is not. Opinion is based off of feelings, personal knowledge, and personal preferences. While useful in some cases, it is not objective.
4) Theory:
A theory is not objective, because it is a opinion that is provable (but is yet to be proven). This makes it subjective, until proven right.
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Answer:
Aerobic Respiration: It is the process of cellular respiration that takes place in the presence of oxygen gas to produce energy from food. This type of respiration is common in most of the plants and animals, birds, humans, and other mammals. In this process, water and carbon dioxide are produced as end products.
The statement that "A clustering appointment type is when patients with similar problems are booked consecutively on the same day" is true. Clustering is type of appointmnet scheduling. In this type of scheduling patients with similar problems are booked consecutively. A block of time is set aside for particular types of cases.
The polar jet stream often plunges southward. When this happens, it can drive cold fronts to regions as far south as Florida. When the polar jet stream plunges south over the United States during the winter time, it is sure that some very cold weather will follow. It changes condensation forms, causes strong storms, thus, transporting cold air.
