Suppose that we study a gene that has been linked to coronary heart disease. We find in a pilot study that in subjects with the
C/ C genotype 20 events have occurred in 200 individuals over a period of 10 years, whereas in subjects with the T/ T genotype 30 events have occurred in 250 individuals in 10 years. Which genotype appears to be associated with a higher prevalence of heart disease?
To know which genotype appears to be associated with a higher prevalence of heart disease, you must know which genotype appeared in the highest percentage in the population tested.
For this, we will do the following calculations.
C/C Genotype:
200 people = 100%
20 people = X
X = (20 * 100) / 200
X = 10%
This means that the C/C genotype appeared in 10% of the tested population.
Now we must to know the percentage of the T / T genotype, we must consider 200 of the 250 people tested.
T/T Genotype:
250 people = 100%
200 people = x
X = (200 * 100) / 250
X = 80%
----
200 people = 80%
30 people = X
X = (30 * 80) / 200
X = 12%
Thus, we can say that the T / T genotype appeared in a higher percentage within the tested population, being considered the genotype that seems to be associated with a higher prevalence of heart disease.
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