Human papillomavirus (HPV) is a double-stranded DNA virus that enters the cytoplasm before undergoing uncoating. Although the vi
rus is replicated by host DNA polymerase in the nucleus, viral replication is closely tied to epithelial cell differentiation. In particular, viral DNA replication is inhibited until __________ are differentiated into ____________, which are ready to be shed from the epithelial layer, increasing the likelihood that HPV will be transmitted to a new host.
The viral DNA replication is inhibited until<u> Basal cells</u> are differentiated into <u>keratinocyte</u>, which are ready to be shed from the epithelial layer, increasing the likelihood that HPV will be transmitted to a new host.
95% of the cells in the epidermis are keratinocytes
Basal cells are multipotent stem cells that are important in the regeneration of homeostasis of the respiratory epithelial cell population.
in skin growth, most of the cells are keratinocytes and they are formed by the division of stem cells in the basal layer
