Question

Pemphigus vulgaris is an autoimmune disorder in humans in which antibodies are produced against the cadherins of desmosomes. The blistering of the skin and mucous membranes characteristic of this disorder is probably a result of ________.

Answer 1

Answer:

The correct answer will be- a loss in the cell-cell adhesion property of the cell.

Explanation:

Pemphigus Vulgaris is a rare disease of the skin which causes blisters on the skin.

The disease is caused by the hypersensitivity reaction in which the antibodies are produced against the desmoglein 1 and 3 of the desmosomes (the structural part which connects the two cells) which binds the layer of skin together.

The loss of desmosomes results in the loss of adhesion between the adjacent cells which disrupts the function of the desmosomes and leads to the rupture of the skin and appears as blisters.

Thus, a loss in the cell-cell adhesion property of the cell is the correct answer.