Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
Learn more about Parkinson's disease brainly.com/question/28169444
#SPJ4
Answer:
lungs and kidneys
Explanation:
The median plane divides the body into two halves through a mid line.
The transverse plain is also known as the axial plane and it divided the body into the upper part and a lower part.
The frontal plane is also known as the coronal plane. It divided the body into the dorsal and ventral sections. The dorsal and ventral sections are the front and back sections ( belly and back).
Lungs and kidneys are the only parts which cannot be seen through all the three plains.
This is false for a number of reasons. While LH (which stands for Leutinizing Hormone) is released by the anterior pituitary gland and can be present in both females and males, it play a more predominant role in females. Working closely with FSH (Follicle Stimulating Hormone) a surge in LH begins the process of ovulation and the development of the Corpeus Leuteum.
In Males it is used both for the production of sperm but to stimulate the production of testosterone.
If its a mutiple choice question ya got then VITAMINS should be the answer
I think the correct answer from the choices listed above is option A. For metamorphism to occur, the parent rock must be in solid form. Metamorphism is the alteration of the structure of a rock by factors like heat and temperature so it must be the material should be in solid form.
