to transmit an output in response to the total afferent input
Explanation:
An effector refers to parts of the body generates response. An effector responds to transmit an output in response to the total afferent input Stimulus in the body are detected by the receptor which send signals to the central nervous system via sensory neuron where interpretation and a response is coordinated by the brain. The response is sent to the effector through the motor neuron.
Drug "Tolerance" is the status of when the body has become accustomed to a medication and requires more to achieve a same affect. Makes sense wouldn't you say.