Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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A nucleic acid is made of nucleotides, and nitrogenous bases are a part of a nucleotide.
DNA is a nucleic acid. The nucleotides in DNA are made up of a sugar (deoxyribose), a phosphate group, and one nitrogenous base (which will be either adenine, guanine, cytosine, or thymine).
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Answer:
a. osteoblasts
b. osteoid
Explanation:
Osteoblasts are the fundamental cell of bone tissue. They are the cells that synthesize the bone matrix called osteoid from which it is made from the skeleton of bone fish, to the skeleton of humans. Since the bone skeleton is an evolutionary paraphiletic characteristic (it is present in several taxonomic groups that have evolved from the same ancestor).
Osteoblasts are responsible for the development and growth of bones during the juvenile stage of individuals and are also responsible for maintaining adult bone and regenerating bone when it breaks.
Osteogenesis is the process of differentiation of osteoblasts. The cells from which osteoblasts differ are called osteoprogenitors. The differentiation of osteoprogenitor cells, which come from the mesoderm, periosteum or bone marrow, is induced by growth factors called bone morphogenetic proteins (BMPs), capable of inducing the growth of bone, cartilage or connective tissue. When an osteoprogenitor cell receives a BMP signal, it quickly begins to express the genes to generate collagen, osteonectin and alkaline phosphatase, among other compounds necessary for bone growth. When the bone grows, it ends up wrapping some of the osteoblasts and they lose their ability to replicate, at that time they are dedicated to bone maintenance and not to their synthesis and are called osteocytes.
Answer:
1-C............. ...............
