I think the answer to this is 2.
Enzymes are protein molecules which serve as catalysts for chemical reactions. A catalyst is a substance which will decrease the activation energy for a reaction. ... Enzymes will make reactions occur much more easily, quickly and more efficiently than they ever would without the enzyme.
Your answer is C
The stream becomes a river
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epithelial layers contain no blood vessels, so they must receive nourishment via diffusion of substances from the underlying connective tissue , through the basement membrane.