There was a boom in fur trading in that time, more Posts were created, artists came and showed a vast wilderness, the Native American people received smallpox and three main tribes almost died off, and they were also placed into reservations. The military also made their presence known.
One example would be the Armenian genocide, in which over 3,000,000 Christians were killed and forced to walk in the desert for months until they no longer had the stamina and died.
