3 years ago

What is the effect of type 2 diabetes (T2D) on pentose phosphate pathway (PPP) flux?

Biology

1 answer:

Serjik [45]3 years ago

3 0

Answer:

Option A is correct

Explanation:

Insulin is responsible for regulating the glucose metabolism through PPP. Insulin increases the G6PD-derived NADPH which regulates several oxido-reductase enzymes. In normal condition, several hormones and nutritional inputs affect the PPP. PPP activity is driven by demand NADPH.

HMG-CoA reductase activity is reduced by G6PD deficiency. G6PD overexpression causes impaired insulin signaling and also increases the level of FFA and TG . Due to impaired insulin signals, the PPP flux increases

Hence, option A is correct

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