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lesantik [10]
3 years ago
12

What is the effect of type 2 diabetes (T2D) on pentose phosphate pathway (PPP) flux?

Biology
1 answer:
Serjik [45]3 years ago
3 0

Answer:

Option A is correct

Explanation:

Insulin is responsible for regulating the glucose metabolism through PPP. Insulin increases the G6PD-derived NADPH which regulates several oxido-reductase enzymes. In normal condition, several hormones and nutritional inputs affect the PPP. PPP activity is driven by demand NADPH.  

HMG-CoA reductase activity is reduced by G6PD deficiency. G6PD overexpression causes impaired insulin signaling and also increases the level of FFA and TG . Due to impaired insulin signals, the PPP flux increases

Hence, option A is correct

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Answer:

I think the question is "How might an RNA-based genome results display an increased in infection rate?" because current statement doesn't convey a message clearly.

Explanation:

To answer this question, we need to understand first that what is gene expression. Gene expression is a process in which genetic information is transcribed first to RNA and then into proteins. During transcription stage, only active genes would be transcribed to RNA and all other DNA material don't transcribe at all. Now, if there is an infection, host cell would express only those genes which would actively take part in the defense mechanism, e.g. R-genes, genes involved in production of reactive oxygen species, etc. Hence, to monitor the infection rate, we will look at the RNA-based genome. To do this, we will extract the total RNA and then would sequence it. Then we will annotate the genes and check the relative abundance (differential expression). Finally, we would have a clear that these genes were active against the infection. By doing temporal sampling and sequencing, we would be able to measure the rate as well.

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